Contents • • • • • • • Function [ ] Cdx2 is the that directs early in. It is required to form the. Ectopic expression of CDX2 was reported in more than 85% of the human patients with (AML). Ectopic expression of Cdx2 in murine bone marrow induced AML in mice and upregulate Hox genes in bone marrow progenitors. CDX2 is also implicated in the pathogenesis of where it has been shown that components from gastroesophageal reflux such as are able to induce the expression of an intestinal differentiation program through up-regulation of NF-κB and CDX2. Biomarker for intestinal cancer [ ] CDX2 is also used in diagnostic surgical pathology as a marker for gastrointestinal differentiation, especially colorectal.

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Possible use in stem cell research [ ] This gene (or, more specifically, the equivalent gene in humans) has come up in the proposal by the, as a solution to the controversy. According to one of the plans put forth, by deactivating the gene, it would not be possible for a properly organized embryo to form, thus providing stem cells without requiring the destruction of an embryo. Other genes that have been proposed for this purpose include, which is required for. Interactions [ ] CDX2 has been shown to with,. References [ ].

18 E1 18 34.41 cM Start 61,018,862 End 61,036,199 pattern Molecular function • • • • • • • • • • • Cellular component • Biological process • • • • • • • • • • • • • Sources: / Species Human Mouse RefSeq (mRNA) RefSeq (protein) Location (UCSC) search Homeobox protein CDX-1 is a in humans that is encoded by the CDX1. CDX1 is expressed in the developing endoderm and its expression persists in the intestine throughout adulthood. CDX1 protein expression varies along the intestine, with high expression in intestinal crypts and diminishing expression along intestinal villi. Contents • • • • Function [ ] This gene is a member of the -related family.

The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.

CDX1 has also been shown to play an important role in embryonic epicardial development. It has been demonstrated that CDX proteins suppress cardiac differentiation in both zebrafish and mouse embryonic stem cells, but the overall mechanism for how this happens is poorly understood.

However, CDX1 has been shown to be transiently expressed in the embryonic heart 11.5 days post coitum (dpc). This transient expression is thought to induce epicardial epithelial-to-mesynchemal transition and thus proper cardiovascular formation. It has been shown that low-dose CDX1 induction caused enhanced migration and differentiation of epicardium-derived cells into vascular smooth muscle, where as continued high dose induction of CDX1 or CDX1 deficiency diminished the ability of these cells to migrate and differentiate into smooth muscle by the actions of TGF-β1. Furthermore, CDX1 induction also altered transcript expression of genes related to cell adhesions for EMT and angiogenesis.

Therefore, along with its known roles in intestinal patterning and differentiation, CDX1 is also shown to be important in epicardial development. References [ ].

• ^ -, May 2017 • ^ -, May 2017 •. • Bonner CA, Loftus SK, Wasmuth JJ (July 1995). 'Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene'.

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